What is diethyl phenylacetyl malonate used for?

 

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Q&A about Diethyl Phenylacetyl Malonate

What is diethyl phenylacetyl malonate used for?

Diethyl phenylacetyl malonate is a compound that is commonly used in organic synthesis as a starting material for the preparation of various pharmaceuticals and agrochemicals. It is specifically known for its role in the synthesis of barbiturates, which are central nervous system depressants used for their sedative-hypnotic properties.

How is diethyl phenylacetyl malonate synthesized?

Diethyl phenylacetyl malonate can be synthesized through a process known as the Claisen condensation. In this reaction, diethyl malonate and phenylacetic acid are reacted together in the presence of a base catalyst, such as sodium ethoxide. The resulting product is diethyl phenylacetyl malonate, which can then be further modified and used in various organic syntheses.

What are some of the key properties of diethyl phenylacetyl malonate?

Diethyl phenylacetyl malonate is a colorless to pale yellow liquid with a fruity odor. It is soluble in organic solvents such as ethanol and acetone, but is insoluble in water. The compound has a melting point of around 25-27°C and a boiling point of approximately 125-130°C. It is important to handle diethyl phenylacetyl malonate with care, as it can be harmful if ingested or inhaled, and may cause irritation to the skin and eyes.In conclusion, diethyl phenylacetyl malonate is a versatile compound that is widely used in the pharmaceutical and agrochemical industries for the synthesis of various important compounds. Its ease of synthesis and functional group reactivity make it a valuable building block for organic chemists working on drug discovery and development.

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