Praziquantel 100 mg
Veterinary Use
Praziquantel Richmond.
Broad spectrum internal antiparasitic for dogs and cats
Indications
Praziquantel Richmond is a broad spectrum internal antiparasitic, indicated for the control of gastrointestinal parasitosis in dogs and cats, caused by cestodes.
Cestodes: Taenia pisiformis, T. hydatigena, T. taeniaformis, Dipylidium caninum, Mesocestoides corti, Echinococcus granulosus, E. multiocularis and Joyeuxiella pasqualei.
Dosage
Dogs: 1 tablet every 20 kg of weight per day orally.
Cats: A quarter of a tablet every 5 kg of weight per day orally.
Equivalent to: Praziquantel 5 mg/kg/day.
Administer the total calculated dose of the product in a single dose. Repeat the treatment after 15 days.
A systematic / preventive deworming plan can also be implemented every 60-90 days.
The interval between doses may be modified by the Veterinarian according to the particular case.
Praziquantel Richmond can be used in pregnant females from the 40th day of pregnancy, in puppies from 30 days of age and in kittens from 6 weeks.
Pharmacokinetics and Bioavailability
Praziquantel:
Praziquantel is, chemically, an isioquinoline. It exhibits high efficacy against cestode parasites at a relatively low dosage.
It is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. In dogs, maximum levels are reached after 30 or 120 minutes. The drug is distributed through all organs and passes to bile in dogs. This distribution is an advantage in the activity of praziquantel against adult or larval forms of cestodes that are located in a very variable way in the host organism (musculature, brain, peritoneal cavity, bile ducts, intestine). It is rapidly metabolized to inactive forms, being the liver the main place of inactivation. Only very low amounts (traces) of the non-metabolized dose are excreted in urine and feces (0.3 % in the dog). It is believed that there must be metabolites that are biologically active in what is excreted given the high efficacy of this drug against intestinal cestodes.
Praziquantel exerts its antiparasitic effect in many ways, affecting both the motility and the proper functioning of the cestode sucking organs (flat worms); induces paralysis of the parasite. Therefore; it joins various anthelmintics that act primarily affecting neuromuscular coordination. The compound also affects the phospholipids and proteins that make up the parasite tegument, which can result in excessive loss of calcium and glucose.
Contraindications and Use Limitations
Anorexy, vomiting, lethargy and diarrhea can occur in dogs.
In cats, adverse effects (salivation, vomiting and diarrhea) are very rare, less than 2%.
Hypersensitive reactions secondary to the release of antigens can occur due to the death of parasites. This happens particularly when the product is administered in high doses.
Because fleas and lice act as intermediate hosts of internal parasites, the measure indicated to ensure the effectiveness of treatment with praziquantel is the application of pulguicides and licecides on the animal and the environment, to interrupt the cycle of life of parasites.
Precautions
Do not administer in weakened animals, or in situations of intense stress.
Verify that the product inviolability system and its storage conditions prior its use are adequate, as well as that it has not expired in reference to the expiration date expressed on the label.
Verify that the product is administered exclusively orally. Do not exceed the propose dose.
Store below 25 ºC, protected from light, in a hygienic place
Always consult your veterinarian
Keep out of reach of children
UNDER VETERINARY PRESCRIPTION ONLY
Protect the environment
Certificate Nº: 02-209
Manufacture by:
LABORATORIOS RICHMOND DIVISION VETERINARIA S.A.
Facility Nº 8589
Fragata Heroína 4988 | C1615ICH | Buenos Aires | Argentina
H.T: Dr. Juan D. Onainty. Méd Vet MN 6167
Made in Argentina
Praziquantel Richmond. Blister containing slotted tablets of 450 mg each.
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